2017 June 26


Neurodegenerative Diseases Laboratory

The laboratory has several facilities: a peptide synthesis and analysis laboratory, a laboratory for protein chemistry and biochemistry, a cell- and tissue culture facility, a fluorescent microscopy laboratory, an animal house and a laboratory for learning and behaviour. The main objectives of the research: elucidation of the molecular mechanisms of protein – misfolding neurodegenerative diseases (Alzheimer’s and Parkinson’s disease, amyotrophic lateral sclerosis) and design and synthesis novel drug candidates for the treatment of these diseases. Two laboratories of the research group are working in the Neurobiological Research Centre at Szeged. Research work of the group is performed in tight cooperation with the Szeged Biological Centre of HAS (MTA-SZK) and BayGen at Szeged. 


Key staff involved

Botond Penke, PhD, DSc, member of the Hungarian Academy of Sciences, Albert Szent-Györgyi and Széchenyi-prize winner. He has worked 45 years on the synthesis and analysis of amino acids, peptides and proteins. He established a computer-aided molecular design laboratory and recently the first Hungarian neuroproteomics laboratory. His main research field now is the Alzheimer’s disease and the amyotrophic lateral sclerosis. He has been the leader of several OTKA and NKTH projects and participant of two EC FP-7 projects (Memoload, LipiDiDiet). He spent 4 years in German, French and USA research centers.

Márta Zarándi, PhD, DSc, has worked 33 years on the synthesis of peptides, biologically active peptide hormones and their analogues as well as peptidomimetics as drug candidates. She spent 9 years in the laboratory of Prof. A. Schally, Nobel-prize winner at the Tulane University, New Orleans, USA. Her research focuses on design and synthesis of peptide analogues using non-coded amino acids, synthesis of putative drug candidates (peptidomimetic compounds).

Lívia Fülöp, PhD, a young coworker of the laboratory has worked for 10 years with the synthesis of peptides and peptidomimetics. Her research focuses on the preparation of β-amiloid peptides and study the aggregation of the peptide to toxic forms like oligomers, protofibrils, fibrils. She uses for studying of protein misfolding dynamic light scattering (DLS), AFM and TEM. Her another research topic is the synthesis of dendrimers, design and synthesis of neuroprotective peptidomimetics. 


Instrumentation

Analytical HPLC equipment
Preparative HPLC equipment
Computer cluster for drug design (80 units) with softwares
Equipment for dynamic light scattering measurement (Zeta sizer)
Fluorescent microscope

Fluoro-plate-reader

Multielectrode array (MEA)


In animal laboratoies:

Mouse - cage system with individual ventilation

Morris water maze appartuses (2 pieces)

NOLDUS camera and software system

Microscope and attachment for quantitative histological evaluation

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Webcam

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